eToxLab provides a comprehensive suite of pharmacological services encompassing in-vitro and in-vivo safety and efficacy assessments within diverse therapeutic areas, including central nervous system (CNS) disorders, metabolic disorders (type 1 and 2 diabetes mellitus, polycystic ovary syndrome), wound healing, autoimmune diseases, hair follicle biology, and gastrointestinal disorders. These investigations utilize a variety of established animal models.
CENTRAL NERVOUS SYSTEM DISORDERS
Chronic Unpredictable Mild Stress (CUMS)-Induced Depression Model
Forced Swim Test
Tail Suspension Test
Locomotor Activity-Actophotometer Test
Novelty Suppressed Feeding Test
Open-field Test
Anxiolytic Activity
Elevated Plus Maze
Light Dark Box Test
Hole Board Test
Marble-burying Test
Anti-convulsant/Antiepilepsy Activity
Isoniazid (INH) Induced-convulsants mouse model
Phenylenetetrazole (PTZ)-induced-seizures mouse model
Maximus electroshock (MES)-induced convulsants mouse model
Neuromuscular/Motor Coordination
Rotarod Test
Antiparkinsonism Disease Activity
MPTP mouse model of Parkinson's Disease
6-hydroxydopamine hydrobromide-induced Parkinson's mouse model
Reserpine-induced Parkinson's Disease
Haloperidol-Induced Catalepsy Test
Memory Enhancer Activity
Scopolamine-induced Amnesia Model
METABOLIC DISORDERS
Diabetes
Streptozotocin-induced type-1 diabetes
Alloxon-induced type-1 diabetes
High-fat diet-induced type-2 diabetes
Streptozotocin and nicotinamide-induced type-2 diabetes
Obesity
High Fat Diet-Induced Obesity in Mouse Model
Hyperlipidemia
Triton-x-100 induced hyperlipidemia in SD rats
PCOS
Letrozole-Induced Poly-cystic ovary syndrome in rat model
Dysmenorrhea
Oxytocin-Induced Dysmenorrhea in rat model
AUTOIMMUNE DISORDERS/INFLAMMATION
Psoriasis
TPA-induced Psoriasis mouse model
Imiquimod (IMQ)-induced Psoriasis mouse model
Ulcerative Colitis
DSS-Induced ulcerative colitis mouse model
TNBS-induced ulcerative colitis mouse model
Oxazolone-induced ulcerative colitis mouse model
Acetic acid-induced ulcerative colitis mouse model
Indomethacin-induced ulcerative colitis rabbit model
Rheumatoid Arthritis
Collagen-induced arthritis mouse model
Freund's Adjuvant-induced arthritis mouse model
PAIN MODELS
Neuropathic Pain Model
Chronic Constriction Injury (CCI) - neuropathic pain
Chemotherapy (Paclitaxel)-induced -neuropathic pain
Streptozotocin (STZ)-induced diabetic neuropathic pain
Inflammatory Pain Models
Carrageenan-induced inflammatory pain model
CFA-induced inflammatory pain model
Nociceptive pain Model
Hot plate Test
Tail flick Test
Tail immersion Test
Formalin-induced paw licking Test
Acetic Acid Writhing Test
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